Sodium Hydroxide → 2-Amino-3-biphenylacetic Acid Hydrate

HRID 325319

반응식

HRID 325319 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13](=[O:16])[CH2:12]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:17].[Na+]>>[OH2:16].[NH2:14][C:15]1[C:11]([CH2:12][C:13]([OH:16])=[O:17])=[CH:10][CH:9]=[CH:8][C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 133019777-phenyl-2,3-dihydro-1H-indol-2-one

생성물 1

HCID 133019802-Amino-3-biphenylacetic Acid Hydrate

실험 절차

A mixture of 4.5 g. (0.0215 mole) of 7-phenylindolin-2-one and 60 ml. of 3 N sodium hydroxide was heated at reflux under nitrogen for 17 hrs. The reaction mixture was cooled, filtered, and the filtrate was diluted with 60 ml. of water. The solution was cooled, made acidic with glacial acetic acid and the resulting tan solid was immediately collected by filtration, washed with cold water and dried under vacuum to yield 4.6 g. (98%) of product as a tan solid, m.p. 98°-100° C. (dec.).

후처리

  1. additionA mixture of 4.5 g
  2. temperatureat reflux under nitrogen for 17 hrs
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered
  5. additionthe filtrate was diluted with 60 ml
  6. temperatureThe solution was cooled
  7. filtrationthe resulting tan solid was immediately collected by filtration
  8. washwashed with cold water
  9. customdried under vacuum
  10. customto yield 4.6 g

출처 및 근거

ORD 기록
ord-dc63a2a4863f4abc8c644aff0c8f8237
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440785

연결된 노트

불러오는 중…