HCID 178488775, 화합물 → 2-(3-Pyridyl)-4-(4-hydroxyphenyl)imidazole
반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[NH:12][CH:13]=2)=[CH:5][CH:4]=1>Br>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:11]2[NH:12][CH:13]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)[N:10]=2)[CH:15]=1참가 물질
3
실험 절차
A mixture of 4-(p-methoxyphenyl)-2-(3-pyridyl)imidazole (2.0 g.) and 48% HBr (100 ml.) is heated to reflux for 20 hrs. After cooling, the precipitate is filtered off and crystallized from isopropanol-methanol to give 2.05 g. of 2-(3-pyridyl)-4-(4-hydroxyphenyl)imidazle of m.p. 315°-318° C.
후처리
- temperatureis heated
- temperatureto reflux for 20 hrs
- temperatureAfter cooling
- filtrationthe precipitate is filtered off
- customcrystallized from isopropanol-methanol
- customto give 2.05 g
출처 및 근거
- ORD 기록
- ord-ebe3842b9a18461ab677b21626116f6d
- 출처 데이터셋
- uspto-grants-1984_04
- 특허 번호
- US04440774
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