Sodium Hydroxide → N-(2-Mercapto-3-methoxybenzoyl)-N-cyclopentylglycine

HRID 325500노트

반응식

HRID 325500 반응식
C([S:4][C:5]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8])(=O)C.[OH-].[Na+]>>[SH:4][C:5]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 20465214N-(2-Acetylthio-3-methoxybenzoyl)-N-cyclopentylglycine

생성물 1

HCID 13599182N-(2-Mercapto-3-methoxybenzoyl)-N-cyclopentylglycine

실험 절차

N-(2-Acetylthio-3-methoxybenzoyl)-N-cyclopentylglycine (4.4 g, 12.5 mmol) was stirred with excess sodium hydroxide solution for 2 hours at 25° C., then acidified and extracted with ethyl acetate. The extract was washed with water and brine, then dried and concentrated. The amorphous product was obtained by column chromatography of the residue.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water and brine
  3. customdried
  4. concentrationconcentrated
  5. customThe amorphous product was obtained by column chromatography of the residue

출처 및 근거

ORD 기록
ord-9b193e6f38bc449bbd4ef12476804a5f
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440941

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