Chloroform → 3-[3-(4-Pentadecenylamino)benzoyl]-4-carboethoxythiazolidine

HRID 325569

반응식

HRID 325569 반응식
Cl.[CH2:2]([NH:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](Cl)=[O:22])[CH2:3][CH2:4][CH:5]=[CH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[S:27]1[CH2:31][CH:30]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[NH:29][CH2:28]1.C(Cl)(Cl)Cl.C(N(CC)CC)C>C(Cl)Cl>[CH2:2]([NH:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([N:29]1[CH:30]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:31][S:27][CH2:28]1)=[O:22])[CH2:3][CH2:4][CH:5]=[CH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

6

반응물 4

HCID 6212ChloroformHCID 8471TriethylamineHCID 103574Ethyl thiazolidine-4-carboxylateHCID 73708083HCID 73708083, 화합물

생성물 1

HCID 538623083-[3-(4-Pentadecenylamino)benzoyl]-4-carboethoxythiazolidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

One-tenth mole of 3-(4-pentadecenylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile.

후처리

  1. filtrationAfter 5 hours at 20° C. the solution is filtered
  2. customevaporated to a white solid which
  3. customis recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-d8d93525a0534249b649b99e88de8c61
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440940

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