Sodium Hydroxide → 1-(3,4-Dichlorophenyl)cyclobutanecarboxamide

HRID 325876

반응식

HRID 325876 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-:15].[Na+]>O.OO.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:13]([NH2:14])=[O:15])[CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

6

반응물 2

HCID 14798Sodium HydroxideHCID 108571341-(3,4-Dichlorophenyl)-1-cyclobutane-carbonitrile

생성물 1

HCID 204630091-(3,4-Dichlorophenyl)cyclobutanecarboxamide

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 784Hydrogen Peroxide용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

A solution of 1-(3,4-dichlorophenyl)-1-cyclobutane carbonitrile (70 g) prepared in a similar manner to that described in Example 1 in industrial methylated spirit (200 ml) was mixed with a solution of sodium hydroxide (3.7 g) in water (5 ml) and 30% hydrogen peroxide solution added dropwise. The mixture was heated at 50° C. for one hour and then stirred with 10% palladium on charcoal (0.5 g) for one hour. The mixture was filtered and evaporated to dryness to give 1-(3,4-dichlorophenyl)-1-cyclobutane-carboxamide.

후처리

  1. additionadded dropwise
  2. filtrationThe mixture was filtered
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d3af89b434f944a4bd977536fff2f96e
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04443449

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