3-Aminopyrrolidine → 2-[1-(Cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine

HRID 32592

반응식

HRID 32592 반응식
[CH3:1][S:2][C:3]1[C:4]2[N:11]=[C:10]([CH:12]=O)[S:9][C:5]=2[N:6]=[CH:7][N:8]=1.NC1C2C=C(C=O)SC=2N=CN=1.NC1CCNC1.[CH:32]1([CH2:38][N:39]2C(C3C=CC=CC=3)=[C:42]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[N:41]=[CH:40]2)[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:50]1([CH2:42][N:41]2[C:12]([C:10]3[S:9][C:5]4[N:6]=[CH:7][N:8]=[C:3]([S:2][CH3:1])[C:4]=4[N:11]=3)=[C:38]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[N:39]=[CH:40]2)[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]1

참가 물질

5

반응물 4

HCID 1644013-AminopyrrolidineHCID 179657987-(Methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde2회HCID 179658194-Aminothieno[2,3-d]pyrimidine-6-carbaldehydeHCID 691948731-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole

생성물 1

HCID 691944402-[1-(Cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine

실험 절차

The title compound was prepared by a similar process to that described for Example 65 but using 7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde (Intermediate 77) in place of 4-aminothieno[2,3-d]pyrimidine-6-carbaldehyde (Intermediate 73) and using cyclohexamethylamine in place of 3-aminopyrrolidine. Yellow solid (542 mg) (the product contained 33% of 1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole but was used in subsequent steps without further purification);

후처리

  1. customwas used in subsequent steps without further purification)

출처 및 근거

ORD 기록
ord-cd391bac60304d50bd71986e166b797d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427616B2

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