Isopropyl chloroacetate → Diisopropyl malonate

HRID 326005

반응식

HRID 326005 반응식
[CH:1]([O:4][C:5](=[O:8])[CH2:6]Cl)([CH3:3])[CH3:2].[OH-:9].[Na+]>C(O)(C)C>[CH:1]([O:4][C:5](=[O:8])[CH2:6][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[O:9])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 7759Isopropyl chloroacetateHCID 14798Sodium Hydroxide

생성물 1

HCID 83223Diisopropyl malonate수율 92%

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

20 g of Co2 (CO)8 in 2.5 liters of isopropanol and 546 g (4 moles) of chloroacetic acid isopropyl ester are placed in a pressure vessel of a capacity of 18 liters, as in Example 1. At 55° C., and a pressure of 5 bars of CO, a 2.93% solution of sodium hydroxide in isopropanol is pumped into the vessel over a period of 3 hours, maintaining a pH of 7.0. At a transformation of 82%, 615 g of malonic acid diisopropyl ester (92% yield) is obtained after the usual processing. 98 g of chloroacetic acid isopropyl ester is recovered.

후처리

  1. temperaturemaintaining a pH of 7.0

출처 및 근거

ORD 기록
ord-ffe40bfa903a41ce950ae81b27983251
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04443624

연결된 노트

불러오는 중…