Ethanol → Pirmagrel

HRID 326117

반응식

HRID 326117 반응식
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:16]2[CH:17]=[N:18][CH:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)=[O:5])C.C(O)C>[OH-].[Na+]>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:16]2[CH:17]=[N:18][CH:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)([OH:5])=[O:3]

참가 물질

4

반응물 2

HCID 702EthanolHCID 132061385-(5-Ethoxycarbonylpentyl)imidazo[1,5-a]pyridine

생성물 1

HCID 55390Pirmagrel

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A suspension of 26 g of 5-(5-ethoxycarbonylpentyl)imidazo[1,5-a]pyridine in 100 ml of 1 N aqueous sodium hydroxide solution is heated on a steam bath for two hours; 10 ml of ethanol is added and heating is continued for 45 minutes. The reaction mixture is cooled, washed with 300 ml of ether and the solution is adjusted to pH 5.5 with concentrated hydrochloric acid. The crystallized product is collected by filtration and washed with 50 ml of water to yield 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine melting at 144°-7°.

후처리

  1. temperatureis heated on a steam bath for two hours
  2. temperatureheating
  3. temperatureThe reaction mixture is cooled
  4. washwashed with 300 ml of ether
  5. filtrationThe crystallized product is collected by filtration
  6. washwashed with 50 ml of water

출처 및 근거

ORD 기록
ord-5ccacb941b484149b208b9aa490042ba
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04444775

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