Hydrochloric Acid → Pirmagrel

HRID 326118

반응식

HRID 326118 반응식
Cl.C(OCC)C.Cl.[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[N:21]2[CH:22]=[N:23][CH:24]=[C:20]2[CH:19]=[CH:18][CH:17]=1)([OH:10])=[O:9]>C(#N)C>[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[N:21]2[CH:22]=[N:23][CH:24]=[C:20]2[CH:19]=[CH:18][CH:17]=1)([OH:10])=[O:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 166380755-(5-Carboxypentyl)imidazo[1,5-a]pyridine hydrochloride

생성물 1

HCID 55390Pirmagrel

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The residue is partitioned between water and methylene chloride after pH is adjusted to 10. The aqueous solution is further washed with chloroform, acidified to pH 1 and again washed with ether and toluene. After pH is adjusted to 5.5, extraction with chloroform gives crude 5-(5-carboxypentyl)imidazo-[1,5-a]pyridine. A solution of the acid in 30 ml of acetonitrile is treated with 5 N ethanolic hydrochloric acid. After addition of 25 ml of ethyl ether, 5-(5-carboxypentyl)imidazo[1,5-a]pyridine hydrochloride, melting at 201°-4°, crystallizes. 5-(5-Carboxypentyl)-imidazo[1,5-a]pyridine (example 2) is obtained on neutralization of a methanolic solution of the salt to pH 5.

후처리

  1. customcrystallizes

출처 및 근거

ORD 기록
ord-1d663802999946fcbf058158c5a98f3b
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04444775

연결된 노트

불러오는 중…