Water → AL 321

HRID 326158노트

반응식

HRID 326158 반응식
[CH3:1][C:2]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH3:21])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([S:18][C:19]#[N:20])[C:13](OCC)=[O:14])=[CH:7][CH:6]=1.[OH2:28]>C(O)C.Cl>[CH3:21][C:2]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([CH3:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]2[S:18][C:19](=[O:28])[NH:20][C:13]2=[O:14])=[CH:7][CH:6]=1

참가 물질

5

반응물 2

HCID 962WaterHCID 12830988HCID 12830988, 화합물

생성물 1

HCID 194620AL 321

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

1.9 g Of ethyl 3-[4-(2-methyl-2-phenylpropyloxy)phenyl]-2-thiocyanatopropionate is dissolved in 20 ml of ethanol and to the solution 20 ml of 6 N-hydrochloric acid is added. The mixture is refluxed for 24 hours. After cooling, water is added to the mixture. The mixture is subjected to extraction with ether. The extract is washed with water and then dried. After distilling off ether, the residure is crystallized from ether-n-hexane, whereby 730 mg of 5-[4-(2-methyl-2-phenylpropyloxy)benzyl]thiazolidine-2,4-dione is obtained.

후처리

  1. additionis added
  2. temperatureThe mixture is refluxed for 24 hours
  3. temperatureAfter cooling
  4. extractionThe mixture is subjected to extraction with ether
  5. washThe extract is washed with water
  6. customdried
  7. distillationAfter distilling off ether
  8. customthe residure is crystallized from ether-n-hexane

출처 및 근거

ORD 기록
ord-a86b4cd079d544eb80fcd767e2c89459
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04444779

반응 노트

불러오는 중…