Bromine → 1-Bromo-4-chloro-2,5-dimethylbenzene

HRID 326179

반응식

HRID 326179 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Cl-].[Al+3].[Cl-].[Cl-].[Br:14]Br>O>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([Br:14])=[CH:4][C:3]=1[CH3:9]

참가 물질

5

반응물 3

HCID 24408BromineHCID 32883Chloro-p-xyleneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 180041871-Bromo-4-chloro-2,5-dimethylbenzene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

400 parts of 2-chloro-p-xylene (b.p.=183° to 184° C.) and 2 parts of anhydrous aluminum chloride were charged into a 1-liter four-necked flask provided with a reflux condenser, a thermometer, a stirrer and a dropping funnel, to which 360 parts of bromine was dropwisely added over a period of 5 hours to carry out the reaction at 35° to 60° C. Water was added to the reaction liquid to wash the same with the thus added water and to remove the catalyst, and then the oil layer was cooled. The separated crystals were filtered, and washed with methanol to obtain 377 parts of 2-chloro-5-bromo-p-xylene having a melting point of 60° to 64° C.

후처리

  1. customprovided with a reflux condenser
  2. customthe reaction at 35° to 60° C
  3. washto wash the same with the thus added water
  4. customto remove the catalyst
  5. temperaturethe oil layer was cooled
  6. filtrationThe separated crystals were filtered
  7. washwashed with methanol

출처 및 근거

ORD 기록
ord-f2c409d37d204f90b69cc7d1b4cfa72c
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04444983

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