2,2,6,6-Tetramethyl-4-piperidone → N-(2,2,6,6-tetramethyl-4-piperidyl)-3-morpholinopropylamine

HRID 326389

반응식

HRID 326389 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][NH2:10])[CH2:3][CH2:2]1.[CH3:11][C:12]1([CH3:21])[CH2:17][C:16](=O)[CH2:15][C:14]([CH3:20])([CH3:19])[NH:13]1>CO>[CH3:11][C:12]1([CH3:21])[CH2:17][CH:16]([NH:10][CH2:9][CH2:8][CH2:7][N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH2:15][C:14]([CH3:20])([CH3:19])[NH:13]1

참가 물질

4

반응물 2

HCID 132202,2,6,6-Tetramethyl-4-piperidoneHCID 61055N-(3-Aminopropyl)morpholine

생성물 1

HCID 19736767N-(2,2,6,6-tetramethyl-4-piperidyl)-3-morpholinopropylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

288.4 g (2 mol) of 3-morpholinopropylamine, 310.5 g (2 mol) of 2,2,6,6-tetramethyl-4-piperidone and 300 ml of methanol are introduced into a 2 litre autoclave; 15 g of 5% Pt-on-carbon are added, and hydrogenation is carried out at 60 bar and 60° C. until the absorption of hydrogen ceases (about 15 hours).

후처리

  1. customhydrogenation is carried out at 60 bar and 60° C. until the absorption of hydrogen ceases (about 15 hours)

출처 및 근거

ORD 기록
ord-da77c7797a634342bdc5c8cedae7aaa1
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05268401

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