Kanamycin A Sulfate → Kanamycin

HRID 326525

반응식

HRID 326525 반응식
[CH2:1]1[C@H:6]([NH2:7])[C@@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][NH2:16])[C@@H:12]([OH:17])[C@H:11]([OH:18])[C@H:10]2[OH:19])[C@H:4]([OH:20])[C@@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][OH:29])[C@@H:25]([OH:30])[C@H:24]([NH2:31])[C@H:23]2[OH:32])[C@@H:2]1[NH2:33].OS(O)(=O)=O>ClCCl>[CH2:1]1[C@H:6]([NH2:7])[C@@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][NH2:16])[C@@H:12]([OH:17])[C@H:11]([OH:18])[C@H:10]2[OH:19])[C@H:4]([OH:20])[C@@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][OH:29])[C@@H:25]([OH:30])[C@H:24]([NH2:31])[C@H:23]2[OH:32])[C@@H:2]1[NH2:33]

참가 물질

3

반응물 1

HCID 441374Kanamycin A Sulfate

생성물 1

HCID 6032Kanamycin

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 125 ml of dichloromethane was added 1 gram of kanamycin sulfate in 10 ml of aqueous solution. To the resulting solution was added 20 ml of soy lecithin (Alcolec S). The solution was mixed by shaking. Four ml of the solution was applied to each side of a 1"×1" foam wound dressing, which was then allowed to dry. These materials were placed in foil heat sealed bags and subjected to sterilization by use of cobalt irradiation (3.2 megarads). The materials were assayed for antibiotic activity as described in Example 12. The eluent contained fully active entrapped antibiotic after irradiation by using standard antimicrobial assay techniques.

후처리

  1. additionThe solution was mixed
  2. customto dry
  3. temperatureheat
  4. customsealed bags
  5. customsubjected to sterilization by use of cobalt irradiation (3.2 megarads)
  6. customafter irradiation

출처 및 근거

ORD 기록
ord-9133486c57974c3d9b83f8017684ae8f
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05269979

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