N,N-Dimethyl-1,3-propanediamine → Palmitamidopropyl Dimethylamine

HRID 326548

반응식

HRID 326548 반응식
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].[C:8](Cl)(=[O:24])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>C(Cl)Cl>[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH:6][C:8](=[O:24])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

참가 물질

4

반응물 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 8206Palmitoyl chloride

생성물 1

HCID 38313Palmitamidopropyl Dimethylamine수율 74%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of N,N-dimethyl-1,3-propanediamine (1.00 mL, 7.95 mmole) in methylene chloride (20 mL) was added palmitoyl chloride (2.19 g, 7.97 mmole). The reaction mixture was stirred at room temperature over night. The solvent was removed under reduced pressure and the residue titurated with diethyl ether. The precipitate (2.34 g) was filtered and stirred in saturated aqueous sodium bicarbonate over night. The precipitate was filtered to give the title compound (2.00 g, 74%) as a white solid. Analysis calculated for C21H43H2O 1.25H2O: C: 69.46; H: 12.91; N: 7.72. Found: C: 69.30 C: 9.46; H: 12.91; N: 7.72 Found: C: 69.30, H: 12.13; H: 12.13; N: 7.58.

후처리

  1. customThe solvent was removed under reduced pressure
  2. filtrationThe precipitate (2.34 g) was filtered
  3. stirringstirred in saturated aqueous sodium bicarbonate over night
  4. filtrationThe precipitate was filtered

출처 및 근거

ORD 기록
ord-8d02029d5a5347078fc1ecd36dbfe303
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270310

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