Hydrochloric Acid → Methyl 2-(4-hydroxyphenoxy)acetate

HRID 326558

반응식

HRID 326558 반응식
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.Cl.[CH3:14]O>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]([O:10][CH3:14])=[O:9])=[CH:11][CH:12]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15881(4-Hydroxyphenoxy)acetic acid

생성물 1

HCID 602731Methyl 2-(4-hydroxyphenoxy)acetate

실험 절차

A solution of 4-hydroxyphenoxyacetic acid (33.6 g) in methanol was treated with hydrogen chloride gas and left to stand at ambient temperature overnight. The solvent was removed in vacuo and the residue taken up in ethyl acetate. This solution was washed sequentially with saturated sodium hydrogen carbonate solution (2×100 ml) and brine (100 ml), then dried (MGSO4) and the solvent evaporated to give methyl 4-hydroxyphenoxyacetate as a colourless crystalline mass, m.p. 112°-114° C.; NMR: 3.8 (s, 3H, CH3), 4.55 (s, 2H, CH2), 6.75 (s, 4H, phenyl-H) 6.8-7.8 (broad s, 1H, OH); m/e 200 (M+NH4)+.

후처리

  1. waitleft
  2. customThe solvent was removed in vacuo
  3. washThis solution was washed sequentially with saturated sodium hydrogen carbonate solution (2×100 ml) and brine (100 ml)
  4. customdried (MGSO4)
  5. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-933771ef539648ec8158ba86dfda7116
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270311

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