Propylamine → N-(1-propyl)-4-hydroxyphenoxyacetamide

HRID 326564

반응식

HRID 326564 반응식
[CH2:1]([NH2:4])[CH2:2][CH3:3].[OH:5][C:6]1[CH:17]=[CH:16][C:9]([O:10][CH2:11][C:12](OC)=[O:13])=[CH:8][CH:7]=1>CO>[CH2:1]([NH:4][C:12](=[O:13])[CH2:11][O:10][C:9]1[CH:16]=[CH:17][C:6]([OH:5])=[CH:7][CH:8]=1)[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 602731Methyl 2-(4-hydroxyphenoxy)acetate

생성물 1

HCID 15730023N-(1-propyl)-4-hydroxyphenoxyacetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-propylamine (4.1 ml) and methyl 4-hydroxyphenoxyacetate (3.64 g) in methanol (50 ml) was left to stand for 72 hours at ambient temperature. The solvent was evaporated in vacuo and the residue taken up in ethyl acetate. The solution was washed sequentially with 1M HCl (2×25 ml) and brine (30 ml), dried (MgSO4) and the solvent evaporated to give N-(1-propyl)-4-hydroxyphenoxyacetamide as a red oil, NMR: 0.95(t, 3H, CH3 ), 1.55(m, 2H, CH2), 3.3(q, 2H, CH2N), 4.4(s, 2H, CH2O), 6.5-6.7(broad s, 1H, OH), 6.8(s, 4H, phenyl-H); m/e 227 (M+NH4)+, 210(M+H)+.

후처리

  1. customThe solvent was evaporated in vacuo
  2. washThe solution was washed sequentially with 1M HCl (2×25 ml) and brine (30 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-5ffffaf14c6b4c27bc5d867700f1db58
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270311

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