4-Methoxybenzenesulfonyl chloride → 4-Methoxybenzenesulfonamide

HRID 326709

반응식

HRID 326709 반응식
[NH4+:1].[OH-].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1>O1CCCC1>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:1])(=[O:13])=[O:12])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 14923Ammonium Hydroxide

생성물 1

HCID 707894-Methoxybenzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

25 ml of 25% NH4OH were added dropwise while cooling in an ice bath to a solution of 7.3 g of p-methoxybenzenesulfonyl chloride in 50 ml of tetrahydrofuran. Subsequently, the reaction mixture was stirred vigorously for 30 minutes at 70° C. (bath temperature). Thereafter, the tetrahydrofuran was distilled. The residue was extracted with ethyl acetate. There was obtained p-methoxybenzenesulfonamide which was converted into the potassium salt as described in Example 50.

후처리

  1. distillationThereafter, the tetrahydrofuran was distilled
  2. extractionThe residue was extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-951efbaa19c74b62ab9164d05a2e3923
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270313

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