Water → HCID 19735046, 화합물

HRID 326719노트

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HRID 326719 반응식
[C:1]([CH:3]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[C:4]([O:6]CC)=[O:5])#[N:2].[OH-].[Na+].O>C(O)C>[C:1]([CH:3]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[C:4]([OH:6])=[O:5])#[N:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 19735035HCID 19735035, 화합물

생성물 1

HCID 19735046HCID 19735046, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-cyano-3-(3-indolyl)propionate (350 mg, 1.45 mmol) (S. Masanori, et al., Heterocycles, 1981, 16: 941-9) was dissolved in ethanol (6 mL). 2N Sodium hydroxide solution (4 mL) was added and the reaction mixture was stirred at ambient temperature for 20 hours. Water (10 mL) was added and the ethanol was removed under reduced pressure. The pH of the aqueous solution was adjusted to approximately 1 with 6N hydrochloric acid solution and it was extracted with ethyl acetate. The ethyl acetate solution was concentrated in vacuo to give the title compound which was carried on to the next step without purification.

후처리

  1. customthe ethanol was removed under reduced pressure
  2. extractionwas extracted with ethyl acetate
  3. concentrationThe ethyl acetate solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-2c93d15d301a4b138cb05278f29b4e5f
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270302

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