Hydrochloric Acid → 2-Cyclohexylacetaldehyde

HRID 326769

반응식

HRID 326769 반응식
C[O:2][CH:3](OC)[CH2:4][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.Cl>O1CCCC1.C(OCC)C>[CH:5]1([CH2:4][CH:3]=[O:2])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 11052116Cyclohexylacetaldehyde dimethyl acetal

생성물 1

HCID 3166272-Cyclohexylacetaldehyde수율 131.7%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 60 gm (349 mMol) cyclohexylacetaldehyde dimethyl acetal in tetrahydrofuran (50 ml) and diethyl ether (100 ml) was added 1N hydrochloric acid (200 ml) and the resulting mixture was stirred for 2.5 hours at room temperature. The reaction mixture was then partitioned between diethyl ether and water. The ether layer was then separated, dried over magnesium sulfate and concentrated under reduced pressure to give 58 gm of crude cyclohexylacetaldehyde.

후처리

  1. customThe reaction mixture was then partitioned between diethyl ether and water
  2. customThe ether layer was then separated
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-630563f85aa847ee93e5ec0548dd74fc
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270328

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