Acetic Anhydride → 2-Acetoxymethyl-4(3H)-pteridinone

HRID 326828

반응식

HRID 326828 반응식
[NH2:1][C:2]1[C:3]([C:8]([NH2:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[C:11]([O:14][C:15](=O)[CH3:16])(=[O:13])[CH3:12]>C(O)C>[C:11]([O:14][CH2:15][C:16]1[NH:10][C:8](=[O:9])[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=1)(=[O:13])[CH3:12]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 280292Aminopyrazine carboxamide

생성물 1

HCID 1354111612-Acetoxymethyl-4(3H)-pteridinone

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Obtained using the procedure described in Example 1, starting with 5.3 g (0.038 mole) of 3-amino-2-pyrazinecarboxamide, 34.5 g (0.157 mole) of triethyl orthoacetoxyacetate and 34.5 ml of acetic anhydride. Refluxing time: 1 hour 45 minutes. Yld: 5.4 g (65%), m.p. 210°-212° C. (ethanol).

후처리

  1. customObtained
  2. temperatureRefluxing time
  3. custom1 hour 45 minutes

출처 및 근거

ORD 기록
ord-b54cc92cbd144d00a1b4e5169937bab9
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270465

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