3-Aminopyrazine-2-carbonitrile → 4-Amino-2-(methoxymethoxymethyl)pteridine

HRID 326841

반응식

HRID 326841 반응식
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH3:10][O:11][CH2:12][O:13][CH2:14][C:15](N)=[NH:16]>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:15]([CH2:14][O:13][CH2:12][O:11][CH3:10])[N:16]=1

참가 물질

4

반응물 2

HCID 8176993-Aminopyrazine-2-carbonitrileHCID 105346532-(Methoxymethoxy)acetamidine

생성물 1

HCID 106804924-Amino-2-(methoxymethoxymethyl)pteridine

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Obtained using the procedure described in section c of Example 2, starting with 12.0 g (0.10 mole) of 3-amino-2-pyrazinecarbonitrile and 18.0 g (0.15 mole) of 2-(methoxymethoxy)acetamidine in 400 ml of absolute ethanol. Refluxing time: 4 hours. Yld: 15.8 g (71%), m.p. 129°-131° C. (ethanol).

후처리

  1. customObtained
  2. temperatureRefluxing time
  3. custom4 hours

출처 및 근거

ORD 기록
ord-241ab9556c384a10bcd413f22b1519f1
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270465

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