Ethyl Acetate → 4-Amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine

HRID 326848

반응식

HRID 326848 반응식
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[F:10][C:11]([F:19])([F:18])[CH2:12][O:13][CH2:14][C:15](N)=[NH:16].C(OCC)(=O)C>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:15]([CH2:14][O:13][CH2:12][C:11]([F:19])([F:18])[F:10])[N:16]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 8176993-Aminopyrazine-2-carbonitrileHCID 105830132-(2,2,2-Trifluoroethoxy)acetamidine

생성물 1

HCID 105391874-Amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Obtained using the procedure described in section c of Example 2, starting with 7.2 g (0.060 mole) of 3-amino-2-pyrazinecarbonitrile and 14.2 g (0.091 mole) of 2-(2,2,2-trifluoroethoxy)acetamidine in 230 ml of absolute ethanol. Refluxing time: 7 hours. Yld: 6.5 g (42%), m p. 145°-147° C. (ethyl acetate).

후처리

  1. customObtained
  2. temperatureRefluxing time
  3. custom7 hours

출처 및 근거

ORD 기록
ord-276bc173ceef417b98d7a35107a2fbe0
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270465

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