Chlorosulfonyl isocyanate → HCID 14722020, 화합물

HRID 326974노트

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HRID 326974 반응식
Cl[S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3].[CH3:8][O:9][C:10]1[CH:19]=[CH:18][CH:17]=[C:12]([C:13]([O:15][CH3:16])=[O:14])[C:11]=1[OH:20]>C1(C)C(C)=CC=CC=1>[CH3:16][O:15][C:13](=[O:14])[C:12]1[CH:17]=[CH:18][CH:19]=[C:10]([O:9][CH3:8])[C:11]=1[O:20][S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 70918Chlorosulfonyl isocyanateHCID 80651Methyl 3-methoxysalicylate

생성물 1

HCID 14722020HCID 14722020, 화합물

시약·촉매·용매 1

HCID 7237O-Xylene용매

반응 조건

온도
140 °C

실험 절차

3.4 g (0.024 mol) of chlorosulfonyl isocyanate are added dropwise to a solution of 3.6 g (0.02 mol) of methyl 3-methoxy-salicylate in 20 ml of xylene at 25° C. When the dropwise addition has ended, the temperature is slowly increased to 140° C. and the mixture is heated under reflux for 2.5 hours. It is cooled and the solvent and excess chlorosulfonyl isocyanate are removed on a rotary evaporator. The yellow oil which remains (5.4 g=1004 of theory) is used without further purification.

후처리

  1. additionWhen the dropwise addition
  2. temperaturethe mixture is heated
  3. temperatureunder reflux for 2.5 hours
  4. temperatureIt is cooled
  5. customthe solvent and excess chlorosulfonyl isocyanate are removed on a rotary evaporator
  6. customis used without further purification

출처 및 근거

ORD 기록
ord-acdd9fd9f7d44198b26daaec0a1a2fd4
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272129

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