Hydrochloric Acid → Propanamide, N-(2,3-dihydro-1H-inden-2-yl)-

HRID 327025

반응식

HRID 327025 반응식
ClCCl.Cl.[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1.[C:15](Cl)(=[O:18])[CH2:16][CH3:17].Cl>C(N(CC)CC)C>[CH2:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:14][CH:6]1[NH:5][C:15](=[O:18])[CH2:16][CH3:17]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 62324Propionyl chlorideHCID 1227642-Aminoindan hydrochloride

생성물 1

HCID 11701165Propanamide, N-(2,3-dihydro-1H-inden-2-yl)-수율 87.2%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

200 ml of dichloromethane, then 15 ml, i.e. 10.9 g (107.6 mmmol) of triethylamine were added to 5 g (29.5 mmol) of 2-aminoindan hydrochloride. The mixture was stirred, then 2.6 ml (29.5 mmol) of propionyl chloride were added and stirring was continued at room temperature for 12 h. Dilute hydrochloric acid was added, the precipitate was filtered, washed, dried and purified by chromatography on a silica gel column, eluted with an 80:20 mixture of dichloromethane/ethyl acetate. 4.87 g of beige solid were isolated.

후처리

  1. stirringstirring
  2. filtrationthe precipitate was filtered
  3. washwashed
  4. customdried
  5. custompurified by chromatography on a silica gel column
  6. washeluted with an 80:20 mixture of dichloromethane/ethyl acetate

출처 및 근거

ORD 기록
ord-d075939707894104a700c725e0acd730
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272157

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