2-Butanamine, 3,3-dimethyl- → N-cyano-N'-(1,2,2-trimethylpropyl)-2-pyridinecarboximidamide

HRID 327089

반응식

HRID 327089 반응식
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][CH:14]([NH2:19])[C:15]([CH3:18])([CH3:17])[CH3:16]>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH:14]([CH3:13])[C:15]([CH3:18])([CH3:17])[CH3:16])#[N:2]

참가 물질

4

반응물 2

HCID 5209072-Butanamine, 3,3-dimethyl-HCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

생성물 1

HCID 19734496N-cyano-N'-(1,2,2-trimethylpropyl)-2-pyridinecarboximidamide수율 93.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 1,2,2-trimethylpropylamine (0.34 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from dichloromethane diethyl ether to give the title compound (0.67 g, 2.9 mmol, yield: 92%) as colorless needles.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from dichloromethane diethyl ether

출처 및 근거

ORD 기록
ord-e0611a07757e4edf98cf6e1d81423ac9
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272164

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