Formic Acid → 4-Methylbenzimidazole

반응식

[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH2:9].[CH:10](O)=O>>[CH3:1][C:2]1[C:3]2[N:9]=[CH:10][NH:8][C:4]=2[CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 175932,3-Diaminotoluene

생성물 1

HCID 15193414-Methylbenzimidazole수율 90%

반응 조건

온도: 70 °C

실험 절차

A mixture of 3-methyl-1,2-benzenediamine (11.9 g) and formic acid (150 mL) was heated at 70° C. for 15 minutes. The solvent was removed under reduced pressure and the residual oil was stirred with water (100 mL) and sodium hydroxide solution (65 mL of 4.0 N) was added until the solution was just basic. The precipitate was filtered off, washed with water, and air dried to give 11.6 g (90%) of 4-methyl-1H-benzimidazole, mp 141°-145° C.

후처리

customThe solvent was removed under reduced pressure
additionwas added until the solution
filtrationThe precipitate was filtered off
washwashed with water, and air
customdried

출처 및 근거

ORD 기록: ord-3592da26c31349c4ad925e57eefe2413
출처 데이터셋: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05273975

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