Ammonia → 3-Chloro-2-methyl-6-nitroaniline

반응식

Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[CH3:12].[NH3:13]>>[Cl:11][C:4]1[C:3]([CH3:12])=[C:2]([NH2:13])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 222Ammonia

HCID 971552,6-Dichloro-3-nitrotoluene

생성물 1

HCID 129530203-Chloro-2-methyl-6-nitroaniline수율 76%

반응 조건

온도: 130 °C

실험 절차

A suspension of 2,6-dichloro-3-nitrotoluene (6.0 g, 29 mmol) in 50% methanolic ammonia (60 mL) was stirred at 130° C. (340 lb pressure) for 18 hours. The autoclave was cooled to -30° C., opened, and the precipitate was filtered off and washed with methanol to give 4.14 g (76%) of 3-chloro-2-methyl-6-nitrobenzenamine.

후처리

temperatureThe autoclave was cooled to -30° C.
filtrationthe precipitate was filtered off
washwashed with methanol

출처 및 근거

ORD 기록: ord-6a783ee54f534c5382fab3da4c85a8fe
출처 데이터셋: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05273975

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