4-Fluorophenol → 4-Fluorophenyl sulfamate

HRID 327727노트

반응식

HRID 327727 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[S:10]([N:13]=C=O)(=[O:12])=[O:11]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][S:10](=[O:12])(=[O:11])[NH2:13])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 97324-FluorophenolHCID 70918Chlorosulfonyl isocyanate

생성물 1

HCID 444592234-Fluorophenyl sulfamate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Using the procedure of Example 84, a mixture of 11.2 g (0.1 mole) of 4-flurophenol and 9.1 ml (0.105 mole) of chlorosulfonyl isocyanate in 50 ml of toluene gave, after recrystallization from benzene, 15.0 g (79%) of the title compound as a white solid, mp 82.5°-85.5° C.

후처리

  1. customgave
  2. customafter recrystallization from benzene, 15.0 g (79%) of the title compound as a white solid, mp 82.5°-85.5° C.

출처 및 근거

ORD 기록
ord-ddd6c9c46a10466499c12f32572ce13f
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273993

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