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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → (3S,8S,9S,10R,13S,14S,16S,17R)-17-[(1R,5R)-6-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,16-diol

HRID 327771
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HRID 327771 반응식
[CH3:1][C@H:2]1[CH2:30][O:29][C@@:5]2([O:9][C@H:8]3[CH2:10][C@H:11]4[C@@H:16]5[CH2:17][CH:18]=[C:19]6[CH2:24][C@@H:23]([OH:25])[CH2:22][CH2:21][C@:20]6([CH3:26])[C@H:15]5[CH2:14][CH2:13][C@:12]4([CH3:27])[C@H:7]3[C@@H:6]2[CH3:28])[CH2:4][CH2:3]1.Cl>[Zn].C(O)C>[OH:9][C@H:8]1[CH2:10][C@@H:11]2[C@:12]([CH3:27])([CH2:13][CH2:14][C@H:15]3[C@H:16]2[CH2:17][CH:18]=[C:19]2[C@:20]3([CH3:26])[CH2:21][CH2:22][C@H:23]([OH:25])[CH2:24]2)[C@H:7]1[C@H:6]([CH3:28])[CH2:5][CH2:4][CH2:3][C@@H:2]([CH3:1])[CH2:30][OH:29]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 99474Diosgenin

생성물 1

HCID 11729441(3S,8S,9S,10R,13S,14S,16S,17R)-17-[(1R,5R)-6-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,16-diol수율 85%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 702Ethanol
용매

실험 절차

To a 5-liter flask were sequentially added diosgenin (40 grams, 0.0965 moles, zinc dust (900 grams, -325 mesh size) and 2 liters of absolute ethanol. The suspension was then brought to reflux and 800 ml of concentrated HCl was added dropwise over a period of 2.5 hours. The reaction was refluxed for an additional 30 minutes then immediately filtered while hot, under gravity, over Whatman no. 2 filter paper to remove the zinc particles. Two liters of water was then added to the filtrate and a white precipitate formed. The mixture was cooled at room temperature and the precipitate was collected by suction filtration (Whatman no. 2 paper) and washed three times with water, then air dried to afford 35 grams (85% yield) of compound (2).

후처리

  1. customTo a 5-liter flask were sequentially added
  2. temperatureto reflux
  3. temperatureThe reaction was refluxed for an additional 30 minutes
  4. filtrationthen immediately filtered while hot, under gravity
  5. filtration2 filter paper
  6. customto remove the zinc particles
  7. additionTwo liters of water was then added to the filtrate
  8. customa white precipitate formed
  9. filtrationthe precipitate was collected by suction filtration (Whatman no
  10. wash2 paper) and washed three times with water
  11. customair dried

출처 및 근거

ORD 기록
ord-b6fa099e9e494e258320e8eb3527737e
출처 데이터셋
uspto-grants-1993_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05274088

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