Acetic Anhydride → HCID 178474341, 화합물

HRID 32793노트

반응식

HRID 32793 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.C([O-])(O)=O.[Na+].[CH3:12][C:13](OC(C)=O)=[O:14]>O>[NH:4]1[CH:5]=[CH:6][C:2]([NH:1][C:13](=[O:14])[CH3:12])=[N:3]1

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178474341HCID 178474341, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 3-aminopyrazole (20 g, 0.24 mol) in H2O (36 mL), at 5-10° C., was slowly added NaHCO3 (9.1 g, mol, 3 eq) and then Ac2O (6.79 ml, 2 eq). The reaction mixture was refluxed for 8 hr. It was cooled down to r.t. and was left standing at this temperature for 12 hr to allow crystallization. The white solid was filtered (12.9 g) and the mother liquor volume was reduced. A second batch of white solid (3.4 g) was obtained after crystallization. The two batches were combined to give the title compound (16.3 g, 54%).

후처리

  1. customat 5-10° C.
  2. temperatureThe reaction mixture was refluxed for 8 hr
  3. waitwas left
  4. customcrystallization
  5. filtrationThe white solid was filtered (12.9 g)

출처 및 근거

ORD 기록
ord-d8cc33e5f25f40949a2c7f8221c44612
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427630B2

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