Hydrogen iodide → 2-(4-Hydroxyphenyl)propionic acid

HRID 328162

반응식

HRID 328162 반응식
[N+]([C:4]1[CH:5]=[C:6]([CH:11]([CH3:15])[C:12]([O-:14])=[O:13])[CH:7]=[CH:8][C:9]=1[OH:10])([O-])=O.COC1C=CC(C(C)C(O)=O)=CC=1.I>>[OH:10][C:9]1[CH:4]=[CH:5][C:6]([CH:11]([CH3:15])[C:12]([OH:14])=[O:13])=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 24841Hydrogen iodideHCID 257576p-Methoxyphenylpropionic acidHCID 21444170HCID 21444170, 화합물

생성물 1

HCID 1025262-(4-Hydroxyphenyl)propionic acid

실험 절차

Also, the compounds (III) used for this invention, for example, 2-(3-nitro-4-hydroxyphenyl)propionate can be prepared by demethylating 2-(4-methoxyphenyl)propionic acid with hydroiodic acid and the like to obtain 2-(4-hydroxyphenyl)- propionic acid, by esterifying the above compound with an usual method to obtain, for example, methyl 2-(4-hydroxyphenyl)propionate and by nitrating the above compounds. Alternately, 2-(3-nitro-4-hydroxyphenyl)propionate can be prepared by nitrating the above 2-(4-hydroxyphenyl)propionic acid with an usual method and by esterificating the resultant compound. The above reactions can be applied to 4-hydroxyphenylacetate as well. The above reaction scheme is shown as follows: ##STR12## wherein R1 has the same meaning as above

후처리

  1. customcan be prepared

출처 및 근거

ORD 기록
ord-76fb6a47486b484f804636832dc37f70
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016193

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