Hydrochloric Acid → HCID 86734627, 화합물

HRID 328203노트

반응식

HRID 328203 반응식
[CH:1]1([N:7]2[CH:14]=[CH:13][C:11]([NH2:12])=[N:10][C:8]2=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:15]([NH:18][C:19]1[CH:28]=[CH:27][C:22]([S:23](Cl)(=[O:25])=[O:24])=[CH:21][CH:20]=1)(=[O:17])[CH3:16].Cl.C1(C2(C=CC(C3N=CC=CN=3)(N)CC2=O)S(N)(=O)=O)CCCCC1>O.N1C=CC=CC=1>[C:15]([NH:18][C:19]1[CH:28]=[CH:27][C:22]([S:23]([NH:12][C:11]2[CH:13]=[CH:14][N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[C:8](=[O:9])[N:10]=2)(=[O:25])=[O:24])=[CH:21][CH:20]=1)(=[O:17])[CH3:16]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8481N-Acetylsulfanilyl chlorideHCID 1930061-CyclohexylcytosineHCID 86734628HCID 86734628, 화합물

생성물 1

HCID 86734627HCID 86734627, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

실험 절차

A mixture of 29.0 g. of 1-cyclohexylcytosine, 90 ml. of pyridine and 35.1 g. of N-acetylsulfanilyl chloride was stirred overnight, poured into 900 ml. of water, and acidified by addition of 80 ml. of concentrated hydrochloric acid. After several hours of vigorous stirring, the precipitated product solidified to yield 33.3 g. of N4 -acetyl-N1 -(1-cyclohexyl-1,2-dihydro-2-oxo-4-pyrimidinyl-sulfanilamide, m.p. 219°-234°. A sample purified by two recrystallizations from ethanol melted at 247°-250°.

후처리

  1. additionA mixture of 29.0 g
  2. additionpoured into 900 ml
  3. waitAfter several hours of vigorous stirring
  4. customto yield 33.3 g
  5. customA sample purified by two recrystallizations from ethanol melted at 247°-250°

출처 및 근거

ORD 기록
ord-d9dabf4ceda741bb885d6cd5f6a6727f
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016267

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