Acetic Anhydride → 5-(Trifluoromethyl)isobenzofuran-1,3-dione

반응식

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[C:6](=[CH:10][CH:11]=1)[C:7](O)=[O:8].C(OC(=O)C)(=O)C>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]2[C:12](=[O:14])[O:13][C:7](=[O:8])[C:6]2=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 5990394-(Trifluoromethyl)phthalic acid

생성물 1

HCID 127177895-(Trifluoromethyl)isobenzofuran-1,3-dione수율 74.7%

실험 절차

4-Trifluoromethyl-phthalic acid (106.6 g.) and acetic anhydride (215 cc.) are heated to the reflux temperature for 30 minutes. After concentration under reduced pressure (30 mm Hg), the residue is stirred with cyclohexane (420 cc.). After filtration and drying, 4-trifluoromethyl-phthalic anhydride (73.5 g.) melting at 54° C is obtained.

후처리

concentrationAfter concentration under reduced pressure (30 mm Hg)
filtrationAfter filtration
customdrying

출처 및 근거

ORD 기록: ord-6eae555cb5c84c91b3e011b3515d54ee
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04016274

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