Hydrazine hydrate (1:1) → 8-Hydroxy-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione

HRID 328322노트

반응식

HRID 328322 반응식
Cl.[OH:2][C:3]1[C:4]([C:20]([OH:22])=O)=[C:5]([C:15](OCC)=[O:16])[CH:6]=[N:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O.[NH2:24][NH2:25]>C(O)C>[OH:2][C:3]1[C:4]2[C:20](=[O:22])[NH:25][NH:24][C:15](=[O:16])[C:5]=2[CH:6]=[N:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 131710706HCID 131710706, 화합물

생성물 1

HCID 123246328-Hydroxy-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2 g. ethyl 5-hydroxy-6-phenylpyridine3,4-dicarboxylate. hydrochloride, 40 ml ethanol and 4 ml hydrazine hydrate was refluxed for 4 hours. After cooling, the pale yellow crystals were recovered by filtration, suspended in 20 ml of water and made acid with dilute hydrochloric acid. The crystals were recovered by filtration, rinsed with water and dried. The procedure provided 1.2 g of 8-hydroxy-7-phenylpyrido[3,4-d]pyridazine-1,4-(2H,3H)-dione, melting point: more than 300° C.

후처리

  1. additionA mixture of 2 g
  2. temperatureAfter cooling
  3. filtrationthe pale yellow crystals were recovered by filtration
  4. filtrationThe crystals were recovered by filtration
  5. washrinsed with water
  6. customdried

출처 및 근거

ORD 기록
ord-1cffaf3e3bae4354b076dead8e515b99
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04017490

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