Diazomethane → 7-chloro-2-[[1-(methoxycarbonyl)-4-(dimethylamino)butylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:21]([OH:23])=[O:22])[CH2:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])[CH2:9][N:8]=[C:7]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3Cl)[C:6]=2[CH:31]=1.[N+](=[CH2:34])=[N-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:21]([O:23][CH3:34])=[O:22])[CH2:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])[CH2:9][N:8]=[C:7]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:6]=2[CH:31]=1참가 물질
3
실험 절차
In the manner given in Example 14, 7-chloro-2-[[1-carboxy-4-(dimethylamino)butylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-chloro-2-[[1-(methoxycarbonyl)-4-(dimethylamino)butylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.
출처 및 근거
- ORD 기록
- ord-310ba3d242764b49b6640af0f392dc05
- 출처 데이터셋
- uspto-grants-1977_04