Chloroacetyl chloride → N-benzyl-N-tert-butyl-2-chloroacetamide

HRID 328626

반응식

HRID 328626 반응식
[CH2:1]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[Cl:15][CH2:16][C:17](Cl)=[O:18]>ClCCCl>[CH2:1]([N:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:17](=[O:18])[CH2:16][Cl:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 76908N-(1,1-Dimethylethyl)benzenemethanamine

생성물 1

HCID 2386050N-benzyl-N-tert-butyl-2-chloroacetamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

To a stirred and cooled mixture of 33 parts of N-benzyl-N-tert.-butylamine in 60 parts of sodium hydroxide solution 20% and 160 parts of 1,2-dichloroethane are added dropwise 34 parts of 2-chloroacetyl chloride at a temperature between -5° and -10° C. Upon completion, stirring is continued at the same temperature for one hour. The reaction mixture is allowed to reach room temperature and the organic layer is separated, washed with water, dried and evaporated, yielding 43 parts of N-benzyl-N-tert.-butyl-2-chloroacetamide as a residue.

후처리

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customto reach room temperature
  4. customthe organic layer is separated
  5. washwashed with water
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-5f90d87b76b841d88b04a4c41097ad9d
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04017631

연결된 노트

불러오는 중…