1,3-Dibromopropane → HCID 21443206, 화합물

HRID 328630노트

반응식

HRID 328630 반응식
[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[OH:11])[CH:2]=[CH2:3].[Br:12][CH2:13][CH2:14][CH2:15]Br.[OH-].[Na+]>O>[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[O:11][CH2:15][CH2:14][CH2:13][Br:12])[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 80011,3-DibromopropaneHCID 14798Sodium HydroxideHCID 113441122-Allyl-4-fluorophenol

생성물 1

HCID 21443206HCID 21443206, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a stirred and refluxing mixture of 162 parts of 2-allyl-4-fluorophenol, 363 parts of 1,3-dibromopropane in 700 parts of water is added dropwise a solution of 56 parts of sodium hydroxide in 175 parts of water. Upon completion, the whole is stirred and refluxed for 8 hours. After cooling, the aqueous layer is separated and extracted with chloroform. The extract is dried over magnesium sulfate, filtered and evaporated. The oily residue is distilled twice, yielding 142 parts of 3-allyl-4-(3-bromopropoxy)fluorobenzene; bp. 160° -170° C. at 14 mm. pressure.

후처리

  1. temperaturerefluxing
  2. stirringUpon completion, the whole is stirred
  3. temperaturerefluxed for 8 hours
  4. temperatureAfter cooling
  5. customthe aqueous layer is separated
  6. extractionextracted with chloroform
  7. dry with materialThe extract is dried over magnesium sulfate
  8. filtrationfiltered
  9. customevaporated
  10. distillationThe oily residue is distilled twice

출처 및 근거

ORD 기록
ord-87b3195e6c63404d8f64072d7ea9afb9
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04017631

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