Chloroform → alpha-Chloro-3-nitrobenzaldoxime

반응식

[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH:7]=[N:8][OH:9])([O-:3])=[O:2].C(Cl)(Cl)[Cl:14]>>[Cl:14][C:7](=[N:8][OH:9])[C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

참가 물질

반응물 2

HCID 6212Chloroform

HCID 2191323-Nitrobenzaldoxime

생성물 1

HCID 2756318alpha-Chloro-3-nitrobenzaldoxime수율 93.7%

실험 절차

32.9 g (0.2 mol) of 3-nitrobenzaldoxime was suspended in 150 g of chloroform and chlorine gas was bubbled into the suspension while maintaining the reaction mixture at a temperature of from 5° to 10° C. 3-Nitrobenzaldoxime went into solution showing a green color upon reaction with chlorine to give a reaction mixture having a deep green color. The reaction mixture turned a pale yellowish-brown upon standing; chloroform was then removed from the reaction mixture under reduced pressure to give 37.6 g of pale yellow crystals having a melting point of 98°-101° C. Yield, 94%.

후처리

customchlorine gas was bubbled into the suspension
temperaturewhile maintaining the reaction mixture at a temperature of from 5° to 10° C
customupon reaction with chlorine
customto give a reaction mixture
customchloroform was then removed from the reaction mixture under reduced pressure

출처 및 근거

ORD 기록: ord-dc39e48f4844465387e4cd39efcfb0d4
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04018645

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