M-Cresol → HCID 4728832, 화합물

반응식

[CH:1]([N:5]1[CH2:8][CH:7]([OH:9])[CH2:6]1)([CH2:3][CH3:4])[CH3:2].[CH:10]1[C:15]([OH:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17]>>[CH3:17][C:11]1[CH:10]=[C:15]([CH:14]=[CH:13][CH:12]=1)[O:16][CH2:6][CH:7]([OH:9])[CH2:8][NH:5][CH:1]([CH2:3][CH3:4])[CH3:2]

참가 물질

반응물 2

HCID 342M-Cresol

HCID 205173831-(1-Methylpropyl)-3-azetidinol

생성물 1

HCID 4728832HCID 4728832, 화합물

실험 절차

1-(sec.-butyl)-3-azetidinol and m-cresol were reacted in the same manner as in Example 6 to yield 1-(3-methyl-phenoxy)-3-(sec.-butylamino)-2-propanol. A hydrochloric acid gas was blown to yield 1-(3-methylphenoxy)-3-(sec.-butylamino)-2-propanol hydrochloride melting at 159°-160° C. The yield was 69%.

출처 및 근거

ORD 기록: ord-4a4cf8a5db384fa08d2744a762e27064
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04018824

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