3-Benzyloxy-1-(tert.butyl)azetidine → 1-tert-Butyl-3-hydroxyazetidine

HRID 328903

반응식

HRID 328903 반응식
C([O:8][CH:9]1[CH2:12][N:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:10]1)C1C=CC=CC=1>[Ni].C(O)C>[C:13]([N:11]1[CH2:12][CH:9]([OH:8])[CH2:10]1)([CH3:16])([CH3:15])[CH3:14]

참가 물질

4

반응물 1

HCID 205173323-Benzyloxy-1-(tert.butyl)azetidine

생성물 1

HCID 2879861-tert-Butyl-3-hydroxyazetidine수율 76%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

A solution of 4.4 parts of 3-benzyloxy-1-(tert.butyl)azetidine in 30 parts of ethanol was taken into an autoclave together with 2 parts of Raney nickel as catalyst. Under a hydrogen gas pressure of 100 atmospheres, the mixture was stirred at 40° C. for 15 hours to perform the reduction. The catalyst was separated by filtration, and the remaining ethanol solution was concentrated to dryness. The resulting oily substance was dissolved in n-hexane and cooled. As a result 2.0 parts of 1-(tert.-butyl)-3-azetidinol melting at 42° - 43° C. The yield was 76%. The results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:

후처리

  1. customThe catalyst was separated by filtration
  2. concentrationthe remaining ethanol solution was concentrated to dryness
  3. dissolutionThe resulting oily substance was dissolved in n-hexane
  4. temperaturecooled

출처 및 근거

ORD 기록
ord-db82225784564761821714242e8703a7
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04018824

연결된 노트

불러오는 중…