Hydrochloric Acid → 3,4-Methylenedioxyphenylalanyl chloride hydrochloride

HRID 329171노트

반응식

[CH2:1]1[O:15][C:14]2[CH:13]=[CH:12][C:5]([CH2:6][C@@H:7]([C:9](O)=[O:10])[NH2:8])=[CH:4][C:3]=2[O:2]1.Cl.P(Cl)(Cl)(Cl)(Cl)[Cl:18].Cl.C1(NCC([Cl:34])=O)C=CC=CC=1>>[ClH:18].[CH2:1]1[O:15][C:14]2[CH:13]=[CH:12][C:5]([CH2:6][C@@H:7]([C:9]([Cl:34])=[O:10])[NH2:8])=[CH:4][C:3]=2[O:2]1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 24819Phosphorus pentachloride

HCID 12918717(S)-2-Amino-3-(benzo[D][1,3]dioxol-5-YL)propanoic acid

HCID 13140662N-Phenylglycyl chloride--hydrogen chloride (1/1)

생성물 1

HCID 867342163,4-Methylenedioxyphenylalanyl chloride hydrochloride

실험 절차

The compound 3,4-methylenedioxyphenylalanine, Ber., 59, 2952 (1926), is treated with hydrogen chloride and phosphorous pentachloride in accordance with the procedure described by Hartcastle et al., J. Org. Chem., 31, 897 (1966) for the preparation of phenylglycyl chloride hydrochloride to yield 3,4-methylenedioxyphenylalanyl chloride hydrochloride.

출처 및 근거

ORD 기록: ord-2c6906adf7194110b7100c74188569f5
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04020060

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