Benzyl Alcohol → HCID 22759231, 화합물

HRID 329295노트

반응식

HRID 329295 반응식
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:11]([CH:14]([CH2:26][CH2:27][CH2:28][CH:29]1[O:31][CH2:30]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=[O:13])[CH3:12]>O>[C:11]([CH:14]([CH2:26][CH2:27][CH2:28][CH:29]([OH:31])[CH2:30][O:10][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][C:25]1[CH:8]=[CH:9][CH:4]=[CH:5][CH:6]=1)=[O:22])(=[O:13])[CH3:12]

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 22759269HCID 22759269, 화합물

생성물 1

HCID 22759231HCID 22759231, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium hydride (0.04 mole) is added in portions with stirring to benzyl alcohol (25 ml.). To the resulting solution, ethyl 8-acetyl-12,13-epoxytridecanoate (0.02 mole) is added and the mixture allowed to stand 18 hours at 55°-60°. The reaction mixture is then cooled and treated with water. The organic layer is separated and dried over magnesium sulfate. Excess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure. The residue consists mainly of the title compound and is used in the next step without purification.

후처리

  1. temperatureThe reaction mixture is then cooled
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulfate
  4. customExcess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure
  5. customis used in the next step without purification

출처 및 근거

ORD 기록
ord-5ad1cb0b87664dcb971bafe4154b64bc
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04020177

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