1-Propanol → HCID 22759335, 화합물

HRID 329303노트

반응식

HRID 329303 반응식
[C:1]([CH:4]([CH2:16][CH2:17][CH2:18][CH:19]1[O:21][CH2:20]1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])(=[O:3])[CH3:2].[CH2:22]([OH:25])[CH2:23][CH3:24].[OH-].[Na+]>O>[C:1]([CH:4]([CH2:16][CH2:17][CH2:18][CH:19]([OH:21])[CH2:20][O:25][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 10311-PropanolHCID 14798Sodium HydroxideHCID 22759269HCID 22759269, 화합물

생성물 1

HCID 22759335HCID 22759335, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of ethyl 8-acetyl-12,13-epoxytridecanoate (14.9 g., 0.05 mole), propanol (60 ml.), sodium hydroxide (6.0 g., 0.15 mole) and water (15 ml.) is stirred 4 hours at 40°-45° and then heated 1 hour on the steam bath. The mixture is cooled, treated with water (250 ml.) and extracted with ether. The aqueous solution is acidified with hydrochloric acid. The oily product is taken up in ether, washed with water, and dried over sodium sulfate. Evaporation of the ether leaves the title compound as a pale yellow oil. Purification is effected by column chromatography on silica gel with 2% methanol in chloroform as the eluant.

후처리

  1. temperatureheated 1 hour on the steam bath
  2. temperatureThe mixture is cooled
  3. extractionextracted with ether
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the ether

출처 및 근거

ORD 기록
ord-6c4ebde4178c45dd971410743b2cafa5
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04020177

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