2-Chloroethanol → Biphenol-diethanol

HRID 329346

반응식

[C:1]1([OH:14])[C:2]([C:7]2[C:8]([OH:13])=[CH:9][CH:10]=[CH:11][CH:12]=2)=[CH:3][CH:4]=[CH:5][CH:6]=1.[OH-].[Na+].Cl[CH2:18][CH2:19][OH:20].[CH2:21]([OH:23])[CH3:22]>>[C:8]1([OH:13])[C:7]([C:2]2[C:1]([OH:14])=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:12]([CH2:22][CH2:21][OH:23])[C:11]([CH2:18][CH2:19][OH:20])=[CH:10][CH:9]=1

참가 물질

반응물 4

HCID 342-Chloroethanol

HCID 702Ethanol2회

HCID 14798Sodium Hydroxide

HCID 15731(1,1'-Biphenyl)-2,2'-diol

생성물 1

HCID 19996287Biphenol-diethanol

실험 절차

To biphenol (0.5 mole) and 200 milliliters of absolute ethanol and sodium hydroxide (1.1 millimole) at 80° C. was added dropwise a solution of 2-chloroethanol (1 mole) in 50 milliliters of absolute ethanol. The mixture was refluxed for 48 hours, and then filtered hot and washed twice with boiling ethanol (100 milliliters). Recrystallization from boiling water provided the precursor product biphenol-diethanol, 80 to 85 percent yield of colorless crystals. The melting point for this product was 210 to 211° C.

후처리

temperatureThe mixture was refluxed for 48 hours
filtrationfiltered hot
washwashed twice with boiling ethanol (100 milliliters)
customRecrystallization

출처 및 근거

ORD 기록: ord-3be03b6fed26496e874c1462685d7a91
출처 데이터셋: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04891293

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