p-Toluenesulfonic acid → HCID 86743630, 화합물

HRID 329355

반응식

HRID 329355 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][NH2:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.CC1C=CC(S(O)(=O)=O)=CC=1.[CH3:24][C@:25]12[CH2:42][CH2:41][C@H:40]3[C@@H:30]([CH2:31][CH2:32][C@@H:33]4[C@:38]3([CH3:39])[CH2:37][CH:36]=[CH:35][CH2:34]4)[C@@H:29]1[CH2:28][CH2:27][C:26]2=O>C(O)C>[CH3:24][C@:25]12[CH2:42][CH2:41][C@H:40]3[C@@H:30]([CH2:31][CH2:32][C@@H:33]4[C@:38]3([CH3:39])[CH2:37][CH:36]=[CH:35][CH2:34]4)[C@@H:29]1[CH2:28][CH2:27][C:26]2=[N:12][NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=1)(=[O:10])=[O:9]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 15303P-ToluenesulfonylhydrazideHCID 1019285alpha-Androst-2-en-17-one

생성물 1

HCID 86743630HCID 86743630, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

4-Methylbenzenesulphonic acid hydrazide (525 g) and 4-methylbenzenesulphonic acid (5.25 g) were added to a hot, stirred solution of (5α)-androst-2-en-17-one (700 g) in ethanol (5.6 l) and the solution was heated under reflux for 8 h. The stirred mixture was cooled and further ethanol (1 l) was added to give 4-methylbenzenesulphonic acid [(5α)-androst-2-en-17-ylidene]hydrazide as a crystalline solid.

후처리

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 8 h
  3. temperatureThe stirred mixture was cooled

출처 및 근거

ORD 기록
ord-38661b3f5a654471835245fa1a2e76d9
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04891366

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