Water → 2-Methyl-3-(oxan-2-yloxy)propan-1-ol

HRID 329790

반응식

HRID 329790 반응식
C([O:9][CH2:10][CH:11]([CH3:20])[CH2:12][O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1)(=O)C1C=CC=CC=1.[OH-].[Na+].O>CO>[CH3:20][CH:11]([CH2:12][O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1)[CH2:10][OH:9]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 147960471-Benzoyloxy-2-methyl-3-tetrahydropyranyloxypropane

생성물 1

HCID 122906532-Methyl-3-(oxan-2-yloxy)propan-1-ol수율 88.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-Benzoyloxy-2-methyl-3-tetrahydropyranyloxypropane (460 mg; 1.65 mmol) was dissolved in methanol (10 ml), and 1M sodium hydroxide solution (3 ml) and water (10 ml) were added thereto, and the resultant mixture was stirred at room temperature for 5 hours. The reaction mixture was extracted with ethyl acetate. The extracts were washed with water and dried over anhydrous magnesium sulfte. The solvent was removed by distillation, and the residue was purified by silica gel column chromatography using a mixture of ethyl acetate and benzene (1:4) to give 2-methyl-3-tetrahydropyranyloxy-1-propanol (254 mg; yield, 88%).

후처리

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. washThe extracts were washed with water
  3. dry with materialdried over anhydrous magnesium sulfte
  4. customThe solvent was removed by distillation
  5. customthe residue was purified by silica gel column chromatography
  6. additiona mixture of ethyl acetate and benzene (1:4)

출처 및 근거

ORD 기록
ord-a1140472211246ecbe800f963780362d
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04892961

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