Hydrochloric Acid → 1,1-Bis(4-pyrrolidinophenyl)ethylene

HRID 329816노트

반응식

[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH:12]([C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)=[CH:16][CH:15]=3)[CH3:13])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:12]([C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:21][CH2:22][CH2:23][CH2:24]4)=[CH:16][CH:15]=3)=[CH2:13])=[CH:10][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 137660851,1-Bis(4-pyrrolidinylphenyl)ethane

생성물 1

HCID 32960211,1-Bis(4-pyrrolidinophenyl)ethylene수율 50%

실험 절차

In the same manner as in 1-2 of Example 1 except for using the thus obtained 1,1-bis(4-pyrrolidinylphenyl)ethane instead of 1,1-bis(4-dimethylaminophenyl)ethane and using hydrochloric acid instead of nitric acid in 1-2 of Example 1, 1,1-bis(4-pyrrolidinylphenyl)ethylene (m.p. 211° C.) was obtained in a yield of about 50%.

출처 및 근거

ORD 기록: ord-20816293d86d4fca86af529b2a427492
출처 데이터셋: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04892973

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