2-Bromopropan-1-ol → Phosphorodichloridic acid-2-bromopropyl ester

HRID 329970노트

반응식

HRID 329970 반응식
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Br:6][CH:7]([CH3:10])[CH2:8][OH:9]>C(Cl)(Cl)(Cl)Cl>[Br:6][CH:7]([CH3:10])[CH2:8][O:9][P:1]([Cl:5])([Cl:3])=[O:2]

참가 물질

4

반응물 2

HCID 117132-Bromopropan-1-olHCID 24813Phosphorus oxychloride

생성물 1

HCID 14256196Phosphorodichloridic acid-2-bromopropyl ester수율 56.7%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매2회

실험 절차

To a solution of 42 g of phosphorous oxychloride in 110 ml of carbon tetrachloride was added dropwise with stirring a solution of 25 g of 2-bromo-1-propanol in 25 ml of carbon tetrachloride. This mixture was stirred overnight, then taken to dryness, evaporated twice from toluene and dried. The residue was distilled on a Kugelrohr 75° C., 0.05 mm, giving 26.1 g of the desired compound as a colorless oil.

후처리

  1. customevaporated twice from toluene
  2. customdried
  3. distillationThe residue was distilled on a Kugelrohr 75° C., 0.05 mm

출처 및 근거

ORD 기록
ord-56fad375b33c4d0ab43d9feb7dbce525
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04894367

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