Bromide ion → Perbenzoic acid

HRID 330094

반응식

HRID 330094 반응식
[C:1]1([Se]Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br-].C1(S(Cl)=O)C=CC=CC=1.[OH:19][OH:20].C[CH2:22][O:23]CC>C(Cl)Cl>[C:22]([O:19][OH:20])(=[O:23])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

7

반응물 5

HCID 259Bromide ionHCID 784Hydrogen PeroxideHCID 3283Diethyl EtherHCID 21928Chloroselenobenzene2회HCID 4190003Benzenesulfinyl chloride

생성물 1

HCID 523077Perbenzoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

In a general description of scheme 1 the diene (2) of step (A) is treated with a halogenating agent such as phenylselenyl chloride or bromide or phenylsulfinyl chloride, preferably phenylselenyl chloride, in an approximately equimolar ratio in an inert solvent at about -80° C., for approximately 20 minutes; illustrative of such inert solvents are methylene chloride, ether and the like. After a standard workup the product residue is dissolved in an ethereal solvent, chilled to about 0° C. and oxidized with an agent such as 30% hydrogen peroxide or a peroxy acid such as peroxybenzoic acid to yield a halohydrin analog (1-3).

후처리

  1. dissolutionAfter a standard workup the product residue is dissolved in an ethereal solvent

출처 및 근거

ORD 기록
ord-206018e1ceb74cfdb888d82f842d23c3
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04894465

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