4-Methyl-5-(2-hydroxyethyl)thiazole → 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

HRID 330107

반응식

HRID 330107 반응식
[OH:1][CH2:2][CH2:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[CH3:9].[CH2:10]([Cl:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[Cl-:17].[CH2:10]([N+:6]1[C:5]([CH3:9])=[C:4]([CH2:3][CH2:2][OH:1])[S:8][CH:7]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 7503Benzyl Chloride

생성물 1

HCID 28333523-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

71.6 g (500 millimoles) of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole), 63.3 g (500 millimoles) of freshly distilled benzyl chloride and 250 ml of absolute acetonitrile are refluxed for 24 hours in a 500 ml round-bottomed flask. The stirred reaction mixture is slowly cooled to room temperature, and the precipitate is filtered off under suction, washed colorless with dry acetonitrile, predried and then dried at 90° C. under reduced pressure from a water pump.

후처리

  1. customThe stirred reaction mixture
  2. filtrationthe precipitate is filtered off under suction
  3. washwashed colorless with dry acetonitrile
  4. dry with materialdried at 90° C. under reduced pressure from a water pump

출처 및 근거

ORD 기록
ord-a5abeb64212d43c2b640956bcae921cb
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04894483

연결된 노트

불러오는 중…